Topic: viral transduction

Glioblastoma is the most lethal brain tumor, partly because of its high intra-tumoral heterogeneity. There are four different glioblastoma subtypes (proneural, mesenchymal, classical and neural) based on their molecular profiles. Distinguishing between each of them is important for physicians in order to choose the appropriate clinical response. For example, proneural glioblastomas are more sensitive to chemotherapy than mesenchymal ones. Since the subtype profiling largely depends on transcriptome analysis, it is not financially practical to perform subtype profiling for every patient. The pr