Experience and reactivation status determine engram synapse structural connectivity
Panthea Nemat, Rolinka J. van der Loo, August B. Smit, Sabine Spijker, Priyanka Rao-Ruiz · FENS Forum 2024
Memory engram cells, activated by learning, undergo input-specific augmentation in their synaptic connectivity (structure, strength and efficacy) to facilitate memory storage and recall. However, only a subset of these cells is reactivated upon retrieval, indicating potential differences in engram cell synaptic connectivity. In this study, we investigated structural synaptic connectivity differences between reactivated and non-reactivated hippocampal CA1 engram cells under conditions of neutral and aversive contextual memory valence. A combination of eGRASP (enhanced green fluorescent protein
ePoster · Neuroscience