Comparing the effects of optogenetic and electrical stimulation of macaque V1 on visual behaviour
Marta Falkowska, Jennifer Greilsamer, Liza Kumari, Jaime Cadena Valencia, Beshoy Agayby, Samy Rima, Marcus Haag, Diego Ghezzi, Michael C. Schmid · FENS Forum 2024
For the long term aim to develop a visual cortical prosthesis, optogenetic stimulation of primary visual cortex (V1) provides a more specific alternative to electrical stimulation. However, adoption of optogenetic techniques from rodents to macaques as an intermediate step towards humans has proven to be challenging. Here we present prelimnary results, directly comparing effects obtained from optogenetic vs electrical stimulation of macaque V1.We injected AAV9-CamKIIa-ChrimsonR-mScarlet-KV2.1 into macaque V1 under electrophysiological guidance. We first investigated neural activity in response
ePoster · Neuroscience