Sensorimotor integration in the zebrafish inferior olive during motor adaptation
Pierce Mullen, Hesho Shaweis, Maarten Zwart · FENS Forum 2024
Neurons in the brainstem's inferior olive (IO) nucleus are pivotal for the control of movement, but their role in motor learning is subject to conflicting hypotheses. One theory posits that IO neurons serve as comparators, signalling prediction errors to the cerebellum by comparing expected and actual sensory feedback. To test this hypothesis, we used two-photon calcium imaging of IO neurons in head-fixed zebrafish (HuC:H2B GCaMP6f) during sensory and motor learning paradigms. We aimed to 1) describe sensory and motor representations in the IO and 2) define responses during triggered motor ada
ePoster · Neuroscience