Orexin knockout mice have compromised orientation discrimination and display reduced AMPAR-mediated excitation in L4-2/3 connections in the primary visual cortex
Cornelia Schöne, Jaya Sowkyadha Sathiyamani, Paloma Renata Huguet Rodríguez, Oliver Marcus Schlüter, Siegrid Löwel · FENS Forum 2024
Lack of lateral hypothalamic orexin/hypocretin (OH) peptides (Sathiyamani et al, accompanying poster) shortens the critical period (CP) for ocular dominance plasticity (ODP) in mouse primary visual cortex (V1). We have previously shown that altered timing of the CP for ODP is caused by modified maturation of AMPA-silent synapses in both PSD-93 and PSD-95 KO mice, and results in compromised orientation discrimination (Favaro et al 2018, PLosBiol 16:e2006838). We therefore analysed whether orexin KO modifies AMPA-currents in V1 and causes similar visual deficits.First, we quantified AMPA-recepto
ePoster · Neuroscience