Untangling the visuomotor circuit in intact and regenerating brains of the axolotl (Ambystoma mexicanum) using behavioral assays, calcium imaging, and optogenetics
Simone Horenkamp, Deniz Demirkesenler, Claudio Polisseni · FENS Forum 2024
Despite the axolotl’s exceptional ability to regenerate complex tissues, little research has focused on this phenomenon in the brain. We aim to understand whether a morphological repair observed during axolotl brain regeneration is accompanied by a functional restoration of neuronal circuits. To do so, we are establishing state-of-the-art neuroscience tools in our model system, namely GCaMP imaging of neuronal activity, behavioral assays and optogenetic stimulation. Using these methods, we will investigate the visuomotor circuit of the axolotl in intact, injured and regenerating conditions.Rec
ePoster · Neuroscience