Topic: voltage clamp recordings

The activity of neurons throughout the brain is determined by the precise relationship between excitatory and inhibitory inputs and disruption of this relationship underlies many psychiatric diseases. Whether these inputs covary over time or between repeated stimuli remains unclear due to the lack of experimental methods for measuring both inputs simultaneously. We developed a new analytical framework for simultaneous measurement of both the excitatory and inhibitory neuronal inputs during a single trial of a current clamp recording. This can be achieved by injecting a current composed of two