Topic: von Frey filament stimulation

Activity of the insular cortex had been consistently suggested to be related with chronic pain. Of the sub-regions in the insular cortex, the posterior insular cortex (pIC) receives inputs from brain regions that receive primary sensory inputs. Anatomical changes of the pIC were reported in neuropathic pain conditions. However, how the activity of pIC neurons may be related with neuropathic pain remain to be investigated. We, therefore, investigated the role of pIC pyramidal neurons and neuropathic pain using optogenetics and fiberphotometry using male mice. We found that inhibiting the activi