Effects of VRK1 deficiency on the neurophysiology and behavior of zebrafish
Magdeline Carrasco Apolinario, Ryohei Umeda, Hitoshi Teranishi, Mengting Shan, Phurpa Phurpa, Nobuyuki Shimizu, Hiroshi Shiraishi, Kenshiro Shikano, Takatoshi Hikida, Toshikatsu Hanada, Reiko Hanada · FENS Forum 2024
Vaccinia-related kinase 1 (VRK1) is a predominantly nuclear serine/threonine kinase implicated in nucleus disassembly and reassembly, cell cycle, and transcription regulation. VRK1 mutations in humans have been linked to several neurodegenerative diseases, including spinal muscular atrophy associated with microcephaly and impaired cognitive and motor function. Thus, it has been identified as potentially involved in the maintenance and development of the nervous system. However, precise pathophysiological mechanisms and VRK1 involvement in cognitive and motor dysfunction progression have yet to
ePoster · Neuroscience