Nicotine biases motivational valence by altering brainstem cholinergic signals
Renan Costa Campos, Hugo Fofo, Paula Pousinha, Mariano Soiza-Reilly, Fabio Marti, Daiana Rigoni, Nicholas Heck, Vanesa Ortiz, Philippe Faure, Sebastian Fernandez, Jacques Barik · FENS Forum 2024
Tobacco smoking is a major contributor to the burden of mental health disease worldwide. Nicotine is the primary reinforcing and main addictive component of tobacco. Nicotine addiction is a chronic relapsing disorder associated with multiple psychiatric comorbidities, and few effective interventions currently exist to curb addiction to nicotine. The neurocircuitry underlying nicotine addiction is broad, complex and depends on the stages of the disease process. It is well-acknowledged that nicotine impacts the reward system with prominent alterations of the firing properties of VTA DA neurons c
ePoster · Neuroscience