A brainstem circuit regulating anxiety with slow-wave sleep
Xiang Feng, Huiying Zhao, Yunting Su, Yan-Qin Yu, Li Sun, Shumin Duan · FENS Forum 2024
Sleep disturbances are commonly linked with and constitute fundamental characteristics of anxiety disorders. However, the effects of actively increased sleep, especially slow wave sleep (SWS), after social defeat stress, on emotion regulation remain unexplored. By inducing time-locked SWS in mice by optogenetically stimulating the SWS promoting center in Vgat-ChR2-eYFP mice, we provide a direct approach to analyze the influences of SWS on anxiety-like behavior. Here we report that SWS induced by photostimulation immediately after social defeat prevents the development of anxiety disorder. We a
ePoster · Neuroscience