Cellular and molecular changes in the medial entorhinal cortex during aging
Sorgog Uzeen, Sihui Cheng, Qichen Cao, Yuanjing Liu, Jiangyuan Liu, Shidan Wen, Chenglin Miao · FENS Forum 2024
Aging-correlated cognitive declines, including deficiencies in spatial orientation and memory, may reflect dysfunction in the hippocampus and medial entorhinal cortex (MEC). However, aging-related changes in MEC at the cellular and molecular levels remain unclear. In this study, we found fewer grid cells with reduced spatial stability in old mice. We compared gene expression profiles between young and old mice using 10x Genomics Visium technology. Among 1664 differentially expressed genes, we discovered a marker gene for subpopulation in MEC Layer III with decreased cell number with age. Silen
ePoster · Neuroscience