Topic: Western-diet

Unlike familiar Alzheimer’s Disease (FAD) which is caused by mutations, most common sporadic disease (SAD) arises from a combination of risk factors including inflammation. This study aimed to explore and compare the effects of two pro-inflammatory agents: Western-diet (WD) and Lipopolysaccharide (LPS) of Gram-negative bacteria on initiation of AD molecular markers in the brain in the absence of AD mutations. To this aim, 3 months-old (mo) male C57BL/6J mice were divided into 3 groups: fed with WD, with Standard Diet (SD-CTR) and SD-fed mice injected 3 times with LPS (0.5mg/kg) at 3 mo. Mice w