Impact of ventral hippocampal chondroitinase-ABC infusion on perineuronal nets and diffuse extracellular matrix in male Lister hooded rats
Jacob Juty, Rachel Grasmeder Allen, Jacco Renstrom, Jennifer Fletcher, Charlotte Taylor, John Gigg, Michael Harte, Tobias Bast · FENS Forum 2024
Perineuronal nets (PNNs) in the hippocampus primarily surround inhibitory interneurons. PNNs have been suggested to regulate synaptic plasticity and support GABAergic inhibition, and PNN disruption has been implicated in brain disorders, including schizophrenia. Yet, the cognitive and behavioural consequences of hippocampal PNN loss largely remain to be studied.The enzyme chondroitinase-ABC (chABC) degrades chondroitin-sulfate proteoglycans (CSPGs), a main component of PNNs and the diffuse extracellular matrix (ECM), and has been used to study PNN function in animal models.Here, we characteris
ePoster · Neuroscience