Neurological phenotypes in primary immunodeficiencies: A fated consequence or a hidden developmental predisposition?
Giulia Demenego, Sara Mancinelli, Rosalba Olga Proce, Vanessa Aragona, Antonella Borreca, Irene Corradini, Eugene Kim, Matteo Miotto, Marco Cremonesi, Katarina Ilic, Edoardo Fraviga, Luca Pellegrino, Davide Pozzi, Raffaele Badolato, Roberto Rusconi, Marinos Kallikourdis, Diana Cash, Michela Matteoli, Simona Lodato · FENS Forum 2024
Individuals affected by Primary immunodeficiency disorders (PIDDs), congenital disorders that severely compromise the immune system, frequently exhibit elevated levels of emotional distress, including depression and anxiety. However, their neurological manifestations are often considered a secondary effect of the patients’ poor quality of life and the potential underlying mechanisms linking genetic alterations in PIDDs to neurological conditions have not been explored so far. We aim to investigate whether genetic alterations in PIDD patients can directly contribute to affecting brain architect
ePoster · Neuroscience