Inhibiting GPR17 corrects myelination defects associated with neonatal hypoxia in mice
Sophie Eckl, Sara Conti, Shuguang Yu, Geraldine Duque Salazar, Zicong Zhang, Joshua Chalif, Yu Zhang, Ryan Donahue, Christopher Elitt, Zhigang He · FENS Forum 2024
White matter injury (WMI) is frequently observed in preterm infants, despite advances in neonatal care. Hypoxia is a key contributing factor which, through heightened vulnerability of preterm newborns, leads to oligodendrocyte dysmaturation, ultimately impairing essential myelination processes. To date, no known effective treatment exists. Considering our recent finding, that inhibiting GPR17 enhances oligodendrocyte progenitor cell (OPC) differentiation and myelination following optic nerve crush, we aimed to investigate the impacts of genetic and pharmacological manipulation in a WMI model.C
ePoster · Neuroscience