Can retina serve as a surrogate marker for cardiovascular risk factor-associated differences in the brain?
Nazife Ayyildiz, Karsten Mueller, Samyogita Hardikar, Frauke Beyer, Cornelia Enzenbach, Ronny Baber, Kerstin Wirkner, Silke Zachariae, Johanna Girbardt, Jordan Hassett, Alfred Anwander, Tobias Elze, Mengyu Wang, A. Veronica Witte, Franziska G. Rauscher, Arno Villringer · FENS Forum 2024
Cardiovascular risk (CVR) factors affect both the retina and the brain. This study investigated whether circumpapillary retinal nerve fiber layer thickness (cpRNFLT) might serve as a surrogate marker of CVR-associated gray-matter density (GMD) and white-matter microstructure (WMM) differences in the brain. We cross-sectionally evaluated retinal Optical Coherence Tomography and brain T1- and Diffusion-weighted Magnetic Resonance Imaging data of the same participant in population-based LIFE-Adult study (Leipzig, Germany). We included 769 participants [44% female, meanAge (SD):54.1(15.8)] in voxe
ePoster · Neuroscience