Topic: white matter tract integrity

Multiple risk factors contribute to the rate of atrophy in brain aging. In large population studies, we have previously shown that adverse life history, mental and cardiovascular health impact brain structure and cognition in later life, in cross-sectional investigations. Here we investigate the impact of multiple psychosocial adversities on brain structure changes in a longitudinal design using the UK Biobank dataset. Imaging-derived phenotypes (IDPs) of grey matter and measures of white matter tract integrity were analysed from two waves of data (94%: 2-3 years difference). IDPs were correct