Topic: whole-brain clearing

Increasing research demonstrates the brain can regulate peripheral immunity. We recently showed that the brain also forms neuronal representations of specific immune responses. We termed these representations as immunengrams. Chemogenetic reactivation of the neuronal ensembles that compromise these immunengrams, specifically in the insular cortex, were sufficient to re-create the original inflammatory state. These findings have major implications for our understanding of how the brain can induce disease based on a mental (sensory or cognitive) trigger. However, critical to our understanding of