Role of the serotonergic dorsal raphe nucleus in mediating the effects of developmental chronic stress in zebrafish
Zoltan Kristof Varga, Lucia Jimenez-Fernandez, Archana Golla, Florence Kermen · FENS Forum 2024
Chronic exposure to stressors is associated with the emergence of psychiatric disorders, but the underlying mechanisms are unclear. We previously showed that developmental chronic unpredictable stress (CUS) diminishes the habituation of dorsal raphe nucleus (DRN) serotonergic (5-HT) neurons to acute stressors and enhances anxiety-like responses. Here, we investigated whether the change in 5-HT DRN habitution underlies CUS-induced behavioural alterations. We exposed larval zebrafish to the CUS, subsequently ablated DRN 5-HT neurons using chemogenetics and assessed different types of anxiety-lik
ePoster · Neuroscience