Topic: WIPI2

The brain, particularly the hippocampus, is sensitive to age-related cellular changes, leading to cognitive deficits. Recent work by our laboratory has demonstrated that autophagy, a catabolic lysosomal-dependant process, is reduced in aged hippocampal neurons, and that restoring autophagy levels is sufficient to improve age-related memory impairment. Nonetheless, the regulatory mechanisms involved in neuronal autophagy decline during aging remain largely unknown. Exploring this question, we found that WD repeat domain phosphoinositide-interacting protein 2 (WIPI2), an important driver of auto