Topic: withdrawal syndrome

Opioids use cause thousands of deaths per year in United States. Lately, several studies have been focused on ibogaine (IBO), a psychoactive alkaloid with the ability to treat drug dependence and reduce withdrawal syndrome. The mechanism by which IBO exerts its anti-addictive effects is unknown. This study aims to identify changes in the gene expression after a single oral dose of IBO in different brain areas. Male and female C57BL/6 mice were treated with 60 mg/kg of IBO by gavage. Four hours post-administration frontal cortex samples of three males and three females were obtained to perform