Distinct trajectories of oligodendrocyte development in the genetic mosaic brain of female mouse model of Fragile X syndrome
Darshana Kalita, Ram Dereddi, Hans Jürgen Solinski, Trung Nghia Vu, Yudi Pawitan, Amit Agarwal · FENS Forum 2024
X-chromosome inactivation (XCI) is an epigenetic process unique to female mammals, and creates a mosaic of cells expressing either the maternal or paternal X-chromosome. Females heterozygous for genes leading to X-linked neurodevelopmental disorders (NDD) exhibit a variety of phenotypes. We hypothesize that variability in the ratio and location of cells expressing the mutant vs wild type (WT) X-chromosome is an underlying cause of phenotypic variability. To investigate this hypothesis, we studied oligodendrocyte (OL) development and myelination in Fragile X syndrome (FXS), a NDD caused by the
ePoster · Neuroscience