Melatonin deficiency related to pinealectomy has an age-specific impact on memory decline in rats through ERK/CREB/BDNF/TrkB signaling in the hippocampus
Jana Tchekalarova, Desislava Krushovlieva, Darina Barbutska, Milena Atanasova, Pavel Rashev, Zlatina Nenchovska, Dimitrinka Atanasova · FENS Forum 2024
Memory decline is considered a normal part of the aging process, while the relationship between melatonin deficit and cognitive functions is complex and not fully understood. The present study explored the role of melatonin deficiency induced in different age stages on changes in recognition and spatial memory in rats. Age-related worsening of memory learning capacity, working and short-term memory, tested in the Y maze, object recognition test, and radial arm maze was detected. Pinealectomy negatively impacted memory capacity in the young adult and middle-aged rats, while old rats were unaffe