The modulatory effects of probiotic administration during pregnancy on offspring neurodevelopmental outcomes under prenatal stress conditions
Mara Ionescu, Clara Deady, Lars Wilmes, Patrick Fitzgerald, Gerard Clarke, Ana-Maria Zagrean, Siobhain O'Mahony · FENS Forum 2024
The intrauterine milieu significantly influences the future health trajectory of offspring, wherein adverse prenatal conditions can induce aberrant fetal neurodevelopment with enduring consequences. Prenatal stress represents a notable adverse condition known to affect offspring health detrimentally, often correlated with dysregulations in gut microbiome composition. Therefore, we aim to investigate the impact of prenatal stress on offspring neurodevelopment and to evaluate the potential mitigative role of probiotics. Randomly chosen pregnant female Wistar rats underwent daily restraint stress
ePoster · Neuroscience