Tyrosine, a non-essential amino acid, has anti-depressive properties in chronic immobilization stress-induced mouse depression model
Hyun Joon Kim, Jae Soon Kang, Ji Hyeong Baek, Hye Jin Chung, Dong Kun Lee, Sang Won Park · FENS Forum 2024
Tyrosine (Y), a non-essential amino acid, is synthesized de novo from phenylalanine and converted into L-DOPA in mammals. In the brain, ROS and RNS are increased both in acute and chronic stress conditions, leading peroxynitrite (PN) production. PN can attack Y residues of functional proteins and turn off their normal functions by nitration, called Y-nitration. Under chronic immobilization stress (CIS), glutamine synthetase (GS) activity is decreased without expression change and the decrement of glutamine (Gln) and glutamate (Glu) is found in the prefrontal cortex (PFC), which results in low-
ePoster · Neuroscience