Microglia brainization: The shift from initial colonization to adult-like dynamics, morphology, and function in the postnatal hippocampus and cerebellum
Marta Pereira-Iglesias, Duncan Martinson, Carles Falco, Rodrigo Senovilla-Ganzo, Ainhoa Plaza-Zabala, Alice Louail, Joel Maldonado-Teixido, Sol Beccari, Jorge Valero, Fernando Garcia-Moreno, Jose A Carrillo, Amanda Sierra · FENS Forum 2024
Microglia,the resident macrophages of the brain,originate from yolk sac progenitors and invade the brain at embryonic stages to progressively become integrated in the parenchyma.However, the mechanisms driving the acquisition of the mature microglia phenotype during development are yet unclear.Our hypothesis is that the intrinsic genetic programs that establish the microglial identity early on are fine-tuned by the brain environment.To test this hypothesis,we focused on the hippocampus and the cerebellum,two structures with protracted development.We found that microglial development occurs in
ePoster · Neuroscience