Purkinje cell vulnerability depends on zebrin molecular identity and cerebellar location in a Christianson syndrome mouse model
Julia Tourbina-Kolomiets, Louis-Charles Masson, Brenda Toscano Márquez, Alanna J. Watt, R Anne McKinney · FENS Forum 2024
Ataxia is a prominent symptom of the X-linked neurodevelopmental/neurodegenerative disorder Christianson Syndrome (CS). A hallmark of ataxia disorders is the death of Purkinje Cells where Purkinje Cell cerebellar location can influence their vulnerability. Purkinje Cells express certain molecules in a highly patterned manner across the cerebellum, the most studied being aldolase C/zebrin-II (zebrin), expressed in parasagittal stripes across the cerebellum. We investigated if either type of Purkinje Cell was more vulnerable in CS using immunohistochemistry, looking specifically at motor lobules
ePoster · Neuroscience