Topic: zQ175

Deficits in sensory perception characterize Huntington disease (HD), alongside motor and cognitive impairments. This study investigates altered cortical network connectivity in HD, focusing on sensory spread, where sensory stimulation provokes more extensive cortical activity in HD model mice compared to wild-type (WT) controls.In vivo, we utilized widefield, mesoscale calcium imaging in the awake, head-fixed zQ175 mouse model of HD, crossed with Thy1-GCaMP mice, expressing GCaMP in cortical pyramidal neurons. In vivo, LED flashes induced visual responses imaged through an intact-skull cranial