Evolution of the psychiatric phenotype in the early stages of a Huntington's disease preclinical model
Baptiste Dayre, Katleen Pinchaud, Peter Vanhoutte, Sandrine Betuing · FENS Forum 2024
Huntington's Disease (HD) is a monogenic and neurodegenerative disorder cause by an abnormal amount of CAG repeats in the exon 1 of the huntingtin gene, responsible for numerous transcriptional and cellular process dysfunctions, leading to neuronal death. HD mainly targets the medium spiny neurons of the striatum and more broadly the corticostriatal pathway, but other brain areas, such as the hippocampus, are also affected at more advanced stages of the disease. These deregulations are responsible for a triad of symtoms, consisting in cognitive and psychiatric symptoms that occur prior to the
ePoster · Neuroscience