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BEHAVIORAL CHARACTERIZATION OF AGED <EM>FMR1 </EM>KNOCKOUT MICE. BASAL PHENOTYPING AND SKF81297-MEDIATED DOPAMINERGIC D1/D5 RECEPTOR MODULATION IN AGED FRAGILE X SYNDROME MOUSE MODEL
Carla del Barco Pousand 3 co-authors
University of Gothenburg, Sahlgrenska Academy
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS02-07PM-317
Presentation
Date TBA
Board: PS02-07PM-317
Event Information
Poster Board
PS02-07PM-317
Poster
View posterAbstract
Fragile X syndrome is the most common inherited cause of intellectual disability and an important monogenic contributor to autism spectrum disorder. Although the Fmr1 knockout (KO) mouse model has been extensively characterized in young animals, less is known about how behavioral phenotypes evolve with aging. This study aimed to perform an age-dependent behavioral characterization of aged Fmr1 KO mice and to assess the effects of dopaminergic D1/D5 receptor activation using the selective agonist SKF81297. Basal phenotyping showed that several behavioral alterations previously described in young Fmr1 KO mice were reduced or absent in aged animals, while some sensitivity differences were preserved in nociceptive responses. Administration of SKF81297 did not result in significant changes across the behavioral tests. Overall, these findings suggest that aging attenuates multiple autism-related behavioral phenotypes in the Fmr1 KO model, and that dopaminergic D1/D5 receptor activation does not induce robust behavioral effects under the present experimental conditions. This work highlights the relevance of age as a modulating factor in preclinical models of neurodevelopmental disorders.
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