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FIRING RATE SUPPRESSION OF THE MEDIAL SEPTUM DURING SPATIAL WORKING MEMORY MAINTENANCE WITHOUT NAVIGATION
Malek Aouadiand 4 co-authors
HUN-REN Institute of Experimental Medicine
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS05-09AM-630
Presentation
Date TBA
Board: PS05-09AM-630
Event Information
Poster Board
PS05-09AM-630
Poster
View posterAbstract
Involvement of the medial septum (MS) in working memory (WM) processes has been demonstrated by lesion studies showing deficits in spatial WM performance, as well as by evidence linking WM maintenance to hippocampal theta oscillations, which depend on the MS. However, the specific activity patterns in the MS that may support WM remain unexplored. To address this, we directly compared MS single-neuron activity in mice performing a two-alternative forced-choice task with and without a WM component. The task involved minimal body movement, enabling dissociation between spatial navigation and WM processes. We found heightened MS engagement during the WM task, characterized by increased firing rates and sustained inhibition during the delay period. In addition, we found less strongly theta-rhythmic neurons in the MS during WM engagement, and they were selectively suppressed neurons during the delay period. These findings suggest an enabling role for the MS in hippocampal WM processing.
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