Poster preview
ePoster
THE HIPPOCAMPAL-PREFRONTAL CIRCUIT REGULATES SPATIAL MEMORY IN ALZHEIMER’S DISEASE MOUSE MODEL
Fang Liulvand 6 co-authors
Center for Excellence in Brain Science and Intelligence Technology (Institute of Neuroscience), Chinese Academy of Sciences
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS05-09AM-110
Presentation
Date TBA
Board: PS05-09AM-110
Event Information
Poster Board
PS05-09AM-110
Poster
View posterAbstract
Patients with Alzheimer's disease (AD) suffer from deficits in spatial memory and broad cognitive functions, which involve the medial prefrontal cortex (mPFC) and hippocampus. Here, we show that the projection from ventral CA1 (vCA1) to mPFC was impaired and the excitability of vCA1-targeted mPFC neurons was decreased in an AD mouse model (5xFAD). Using chronic chemogenetic and optogenetic approaches, we found that activating the hippocampal-prefrontal circuit alleviated memory dysfunctions in 5xFAD mice and led to long-lasting rescue after the circuit manipulation. Finally, we combined a spatial task with transcranial direct current stimulation (tDCS), a clinical manipulation approach, to effectively activate the hippocampal-prefrontal circuit in 5xFAD mice. Such spatial-task-combined tDCS effectively enhanced spatial memory across multiple spatial tasks, indicating a general rescue effect. Thus, the hippocampal-prefrontal circuit is critical for spatial memory and could be a therapeutic target for the treatment of memory dysfunctions in AD.
Recommended posters
ENHANCING DORSOLATERAL STRIATUM ACTIVITY AS A COMPENSATORY STRATEGY IMPROVES SPATIAL MEMORY IN A MOUSE MODEL OF ALZHEIMER’S DISEASE
Alessia Frenza, Valentina Latina, Edoardo Uliva, Maria Francesca Criscuolo, Serena Pugliano, Andrea Mele, Giuseppina Amadoro, Arianna Rinaldi
TRANSIENT ACTIVATION OF HIPPOCAMPAL PV NEURONS INDUCES LONG-LASTING COGNITIVE RESCUE IN A MOUSE MODEL OF ALZHEIMER’S DISEASE
Fanny Tixier, Camille Lejards, Laure Verret
EFFECTS OF SELECTIVE STIMULATION OF MEDIAL SEPTAL CHOLINERGIC NEURONS ON ALZHEIMER’S DISEASE PATHOLOGY IN A TRANSGENIC MOUSE MODEL
Alexandra Júlia Hencz, Adrienn Szabó, Dorottya Csiszár, Dóra Zelena
FUNCTIONAL AND STRUCTURAL ALTERATIONS IN THE MAMMILLARY BODIES IN A MOUSE MODEL OF ALZHEIMER’S DISEASE
Xiaoyu Yang, Zahra Lashkari, Delia Chiu, Melika Kashizenuzi, Lara Chirich Barrerira, Gina Krause, Anja Oelschlegel, Katarzyna M. Grochowska, Michael R. Kreutz, Anne Albrecht, Brett Carter, Anne Petzold, Oliver Barnstedt
REINFORCED HIPPOCAMPUS-ACCUMBENS PATHWAY MARKS A SHIFT TOWARDS COGNITIVE DECLINE IN AGING
Aurore Ribera, Brenda Fernandes-Dias, Larissa Yugay, Emma Deneuville, Manuel Dias-Silva, Marion Violain, Thibault Bouet, Ingrid Bethus, Luisa V Lopes, Peter Vanhoutte, Stephen Ramanoël, Jacques Barik, Paula A Pousinha
DEEP BRAIN STIMULATION OF THE HIPPOCAMPAL FORMATION DURING A VISUOSPATIAL ASSOCIATIVE MEMORY TASK IN NON-HUMAN PRIMATES
Adrien Boissenin, Ankur Gupta, Nikolaos Vardalakis, Hugues Orignac, Tho Hai Nguyen, Amirouche Sadoun, Fabien Wagner