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HUMAN MILK OLIGOSACCHARIDES AS BIOACTIVE REGULATORS OF SYNAPTIC DEVELOPMENT
Sabine Léviand 3 co-authors
ESPCI CNRS UMR8249
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS06-09PM-301
Presentation
Date TBA
Board: PS06-09PM-301
Event Information
Poster Board
PS06-09PM-301
Poster
View posterAbstract
Breastfeeding is the optimal source of nutrition for infants, as recommended by the World Health Organization. Its uniqueness lies in its rich composition in nutrients such as carbohydrates, lipides, proteins, along with numerous bioactive elements including hormones, growth factors and oligosaccharides. Among these, human milk oligosaccharides (HMOs) represent the third most abundant group of bioactive substrates in breast milk. They exhibit a great structural complexity with over 150 HMOs identified to date. The early postnatal period represents a critical window for the development, especially for the nervous system characterised by intense maturational processes such as synaptic connectivity and neuronal network establishments. Based on their composition HMOs can be classified into three major categories: fucosylated, sialylated and neutral. Previous studies have shown that fucosylated and sialylated HMOs, when supplemented during the lactation support neurocognitive development, however the mechanisms underlying these effects remain unclear. Here, we investigated the effects of six abundant human milk oligosaccharides (HMOs) in primary hippocampal cultures during the peak period of synaptogenesis, using complementary structural and functional assays. Our results demonstrate that in vitro exposure to fucosylated (2’FL, 3’FL) HMOs increases the density of inhibitory synapses, whereas sialylated (3’SL, 6’SL) HMOs modulate the density of synaptic proteins at both glutamatergic and GABAergic synapses, while neutral (LNT, LNnT) HMOs show no detectable effect. Together, these findings indicate that specific HMO subclasses differentially regulate synapse formation and maturation during lactation.
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