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ePoster
INDUCIBLE HUMAN YOLK SAC MYELOID PROGENITORS MODEL MYELOID ONTOGENY AND ENABLE MICROGLIA AND MACROPHAGE CELL REPLACEMENT <EM>IN VIVO</EM>
Anna Martinez-Murianaand 15 co-authors
Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB)
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS01-07AM-134
Presentation
Date TBA
Board: PS01-07AM-134
Event Information
Poster Board
PS01-07AM-134
Poster
View posterAbstract
Tissue resident macrophages (TRMs) are involved in the surveillance and maintenance of tissue homeostasis, yet their dysfunction is a hallmark of diverse human diseases. Although mouse TRMs arise from sequential migrations of yolk sac progenitors, limited access to human embryonic tissue has hindered the study of human TRMs origin and dynamics. Here, we developed an in vitro system that generates inducible human yolk sac myeloid progenitors (iYSMPs) to model human myeloid ontogeny. iYSMPs share the transcriptomic profile of human yolk-sac progenitors from human embryos and have multipotency to differentiate into macrophages, granulocytes and erythroid lineages in vitro, mimicking human ontogeny. Upon systemic xenotransplantation, iYSMPs acquire organ-specific TRM identities and differentiate into microglia, border associated macrophages, Kupffer cells, cardiac and renal macrophages. This breakthrough defines a human yolk sac progenitor state with broad TRM potential, opening avenues for investigating human myeloid ontogeny and developing innovative microglia and macrophage cell replacement therapies to treat human diseases.
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