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INVESTIGATING MITOCHONDRIA IN THE PATHOPHYSIOLOGY OF BIPOLAR DISORDER AND THE MECHANISM OF LITHIUM RESPONSE
Lucy Maibachand 2 co-authors
Sahlgrenska University Hospital
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS02-07PM-247
Presentation
Date TBA
Board: PS02-07PM-247
Event Information
Poster Board
PS02-07PM-247
Poster
View posterAbstract
People with bipolar disorder (BD) experience (hypo)manic and depressive episodes, reflecting profound shifts in energy and mood. Mitochondria are potential contributors to these characteristic energy shifts and their treatment. While lithium remains the gold-standard treatment, its mechanism of action is incompletely understood and only one-third of patients respond fully. Results suggesting that lithium corrects mitochondrial dysfunction are limited to lithium-responsive patients and remain conflicting. A deeper understanding of mitochondrial involvement in BD pathophysiology and its role in lithium’s mechanism of action is critical to improve treatment for lithium-nonresponsive BD patients. This project adds to deciphering the role of mitochondria in BD pathophysiology and in lithium's treatment mechanism using BD patient derived iPSC models stratified by lithium response. We will create a cohort of differentiated BD-patient derived and control iPSCs and phenotype these in terms of gene expression and function. Changes in the phenotype will be compared between lithium responders and non-responders after lithium treatment.
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