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ePoster
MICROGLIAL REGULATION OF SYNAPTIC PLASTICITY: MECHANISMS OF DE NOVO SYNAPSE FORMATION IN THE ADULT BRAIN
Laetitia Weinhard
ENS
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS05-09AM-489
Presentation
Date TBA
Board: PS05-09AM-489
Event Information
Poster Board
PS05-09AM-489
Poster
View posterAbstract
Microglia are well established as the brain’s primary phagocytes, yet emerging evidence indicates that they also act as active modulators of neuronal circuitry beyond synaptic pruning. Although microglia have been shown to promote synapse formation during early postnatal development, it remains unclear whether this facilitatory role persists in adulthood and which mechanisms underlie such interactions. Here, we investigated the contribution of microglia to synapse formation in the mature brain. Using a combination of genetic approaches, two-photon in vivo imaging, and electron microscopy, we systematically characterized microglia–neuron interactions in the motor cortex, prefrontal cortex, and hippocampus, and examined candidate mechanisms involved in these processes. Our results demonstrate that microglia are required for efficient synapse formation in the adult brain, revealing a previously underappreciated role for microglia in regulating synaptic plasticity beyond development.
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