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ePoster
QUEST FOR PRECISION: ENHANCING SPATIAL PRECISION IN CELLULAR ULTRASTRUCTURE THROUGH ADVANCED CLEM
Minkyo Jung
Korea Brain Research Institute
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS05-09AM-046
Presentation
Date TBA
Board: PS05-09AM-046
Event Information
Poster Board
PS05-09AM-046
Poster
View posterAbstract
Microscopy is a fundamental tool for deciphering the complex mechanisms of biological specimen. While electron microscopy (EM) offers unparalleled nanometer-scale resolution for observing macromolecular complexes and cellular organelles, it often lacks the capacity to capture dynamic molecular functions in live cells. To bridge this gap, Correlative Light and Electron Microscopy (CLEM) has emerged as a powerful multimodal imaging strategy. CLEM integrates the molecular specificity of fluorescence microscopy (FM) with the high-resolution ultrastructural context of EM, allowing for the precise analysis of specific regions of interest identified by fluorescent signaling. This presentation introduces the fundamental principles and the latest methodological protocols in CLEM technology. Through various application cases, we will demonstrate how this technique contributes to elucidating the structure-function relationships within cells and tissues with precision. CLEM overcomes the limitations of conventional microscopy techniques in life science research, offering a new paradigm for understanding complex biological phenomena.
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