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SPATIOTEMPORAL EXPRESSION OF THE C-TYPE LECTIN CD93 IN A MOUSE MODEL OF SPINAL CORD INJURY
Melina Haritopoulou-Sinanidouand 4 co-authors
The University of Queensland
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS04-08PM-115
Presentation
Date TBA
Board: PS04-08PM-115
Event Information
Poster Board
PS04-08PM-115
Poster
View posterAbstract
CD93, also known as C1qRp, is a transmembrane protein historically implicated in endothelial cell function and angiogenesis. Emerging evidence now also supports a broader role for CD93 in immune regulation and ECM remodelling. Interestingly, CD93 has been associated with both protective and pathological responses, with this duality seemingly dependent on the disease context. We identified CD93 as being upregulated in traumatic spinal cord injury (SCI), a condition marked by chronic dysregulated inflammation and scarring, but its role in this pathology remains poorly understood.
We performed single-cell RNA sequencing (scRNA-seq) and immunofluorescent staining to map CD93 expression at various time points (up to 42 days) after contusive SCI in mice. We used cell marker genes and antibody approaches, respectively, to identify the various cell types expressing CD93.
We found that CD93 is robustly expressed at the site of SCI in association with both blood vessels and myeloid cells, including subsets of neutrophils, monocytes and/or monocyte-derived macrophages, and microglia. These findings provide a basis to further explore a functional role for CD93 in relation to neuroinflammation and spinal cord wound healing after injury.
We performed single-cell RNA sequencing (scRNA-seq) and immunofluorescent staining to map CD93 expression at various time points (up to 42 days) after contusive SCI in mice. We used cell marker genes and antibody approaches, respectively, to identify the various cell types expressing CD93.
We found that CD93 is robustly expressed at the site of SCI in association with both blood vessels and myeloid cells, including subsets of neutrophils, monocytes and/or monocyte-derived macrophages, and microglia. These findings provide a basis to further explore a functional role for CD93 in relation to neuroinflammation and spinal cord wound healing after injury.
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