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SUBSECOND TEMPORAL RESOLUTION REVEALS THE ELECTRICAL NATURE OF MAGNETOELECTRIC NANOPARTICLE-MEDIATED NEUROMODULATION
Elric Zhangand 10 co-authors
ETH Zurich
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS01-07AM-408
Presentation
Date TBA
Board: PS01-07AM-408
Event Information
Poster Board
PS01-07AM-408
Poster
View posterAbstract
Magnetoelectric (ME) nanoparticles offer minimally-invasive neuromodulation by using these nano-scale transducers to convert sub-threshold, externally applied magnetic fields into hyper-localized, stimulating electric fields. However, whether ME stimulation achieves the spatiotemporal fidelity of conventional electrodes remains unresolved. We employed calcium imaging and high-temporal-resolution electrophysiology to test whether ME-mediated neural activation exhibits subsecond kinetics expected of field-based electrical stimulation.
In vitro, ME-stimulated neurons exhibited action potential kinetics with minimal jitter (<50 ms). In vivo, forelimb motor evoked potentials appeared at < 1ms post-stimulus, accounting for conduction times, consistent with direct monosynaptic motor cortex activation. These subsecond latencies provide direct evidence that ME nanoparticles mediate neural activation through rapid electrical mechanisms rather than slower secondary processes (mechanical, thermal, or chemical) and validates that ME-field coupling is instantaneous and nanoscale-localized. By establishing temporal response characteristics as a biosignature of ME efficacy, our findings enable translation toward clinical applications while revealing mechanistic insights into nanoscale bioelectrical interfaces.
In vitro, ME-stimulated neurons exhibited action potential kinetics with minimal jitter (<50 ms). In vivo, forelimb motor evoked potentials appeared at < 1ms post-stimulus, accounting for conduction times, consistent with direct monosynaptic motor cortex activation. These subsecond latencies provide direct evidence that ME nanoparticles mediate neural activation through rapid electrical mechanisms rather than slower secondary processes (mechanical, thermal, or chemical) and validates that ME-field coupling is instantaneous and nanoscale-localized. By establishing temporal response characteristics as a biosignature of ME efficacy, our findings enable translation toward clinical applications while revealing mechanistic insights into nanoscale bioelectrical interfaces.
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