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ePoster
URETHANE SUPPRESSES PERSISTENT SPIKING
Anna Bronecand 2 co-authors
Humboldt-Universität zu Berlin
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS06-09PM-234
Presentation
Date TBA
Board: PS06-09PM-234
Event Information
Poster Board
PS06-09PM-234
Poster
View posterAbstract
Urethane is a widely used anaesthetic tool in neuroscience, mainly used for long-lasting experimental paradigms. Despite its frequent usage, the cellular mechanisms underlying its anaesthetic action remain poorly understood. Here, we investigated the effects of urethane on intrinsic neuronal firing properties using ex vivo whole-cell patch-clamp recordings in brain slices. We found that urethane blocked persistent spiking in multiple neuronal subtypes in a concentration dependent manner. This indicates that urethane suppresses neuronal activity by inhibiting sodium action potentials. Our findings suggest that urethane interferes with mechanisms supporting signal integration and transfer, thought to be essential for conscious perception. These results also have important implications for the interpretation of neuronal activity and network dynamics recorded under urethane anaesthesia.
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