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VISUAL STIMULATION AS A NEUROMODULATORY STRATEGY INDUCING HIPPOCAMPAL STABILITY AND PREVENTING COGNITIVE DECLINE AFTER STROKE
Kareen Halablaband 5 co-authors
Institute for Stroke and Dementia Research (ISD), LMU University Hospital, LMU Munich
FENS Forum 2026 (2026)
Barcelona, Spain
Board PS04-08PM-574
Presentation
Date TBA
Board: PS04-08PM-574
Event Information
Poster Board
PS04-08PM-574
Poster
View posterAbstract
Cognitive deficits affect over 70% of stroke survivors, yet the mechanisms by which multiple small ischemic events contribute to cognitive decline remain poorly understood. In this study, we investigated the impact of brain-wide microsctrokes on cognitive function in mice using a virtual reality navigation task, with a focus on the hippocampus. We applied visual stimulation with different frequencies as treatment following microstrokes to assess its potential for ameliorating cognitive impairment. Our findings show that, similar to previous findings (Heiser et al. 2025), microstrokes caused disruptions in spatial memory coding. Interestingly, light flickering treatment restored a degree of stability in the hippocampal network, with treated mice showing improved spatial memory performance. In parallel, single-nuclei RNA sequencing revealed molecular differences upon treatment, and structural tracing using biotinylated dextran amine (BDA) demonstrated that treatment promoted structural reorganization of hippocampal projections following injury. This study provides insights into molecular, structural, and network alterations following stroke, offering a potential avenue for non-invasive therapeutic interventions to prevent or reverse cognitive decline following stroke.
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