The theme examines how developments in brain science and technology are reshaping central questions of neuroethics, from identity, agency, privacy and responsibility to care, justice, consciousness and meaning, starting from the premise that the brain is part of embodied lives shaped by relationships, environments, cultures, health systems and digital ecosystems. As brain data are increasingly linked with biometric, behavioural, clinical, environmental and digital data, and as attention to the exposome grows, the meeting calls for interdisciplinary dialogue between neuroscience, clinical practice, ethics, law, governance, the humanities and people directly affected by neurotechnology. Areas include neurotechnology, brain–computer interfaces, artificial intelligence, neurodata governance, mental health, clinical care, disability, dementia, enhancement, human rights, public engagement, research ethics, global and environmental neuroethics and the humanities. Featured tracks: Thinking + Context; Body + Mind; Data, AI + Self-Knowledge; Boundaries + Limits; Connection + Conflict; and Brain Death + Organ Donation. The in-person meeting takes place at two neighbouring venues in Madrid’s Chamberí district, with online participation for people around the world.