binocular vision

Development and evolution of neuronal connectivity

In most animal species including humans, commissural axons connect neurons on the left and right side of the nervous system. In humans, abnormal axon midline crossing during development causes a whole range of neurological disorders ranging from congenital mirror movements, horizontal gaze palsy, scoliosis or binocular vision deficits. The mechanisms which guide axons across the CNS midline were thought to be evolutionary conserved but our recent results suggesting that they differ across vertebrates.  I will discuss the evolution of visual projection laterality during vertebrate evolution.  In most vertebrates, camera-style eyes contain retinal ganglion cell (RGC) neurons projecting to visual centers on both sides of the brain. However, in fish, RGCs are thought to only innervate the contralateral side. Using 3D imaging and tissue clearing we found that bilateral visual projections exist in non-teleost fishes. We also found that the developmental program specifying visual system laterality differs between fishes and mammals. We are currently using various strategies to discover genes controlling the development of visual projections. I will also present ongoing work using 3D imaging techniques to study the development of the visual system in human embryo.

Fantastic windows of sensitivity and where to find them

Untitled Seminar

Laura Fenlon (Australia): Time shapes all brains: timing of a conserved transcriptional network underlies divergent cortical connectivity routes in mammalian brain development and evolution; Laurent Nguyen (Belgium): Regulation of cerebral cortex morphogenesis by migrating cells; Carol Ann Mason (USA): Wiring the eye to brain for binocular vision: lessons from the albino visual system. Thomas Perlmann (Sweden): Interrogating dopamine neuron development at the single cell level

Untitled Seminar

Isabelle Brunet (France) – Neurovascular development Debby Silver (USA) - Dynamic post-transcriptional control of cortical development Robin Vigouroux (France) – Evolution of binocular vision Patricia Garcez (Brazil) – Beyond microcephaly: how Zika virus impacts brain development

Untitled Seminar

A/Prof Jess Nithianantharajah , Group leader at the Florey Melbourne France will talk about "Molecular components of flexible behaviour” and Dr Robin Vigouroux from the La Vision Institute, Paris France will deal with the "Evolution of binocular vision” .

Compromised binocular vision and reduced binocularity in the visual cortex of postsynaptic density 95 (PSD-95) knock-out mice

FENS Forum 2024