cellular models

Molecular and cellular mechanisms controlling neural stem cell activity

Neural stem cells (NSCs) generate new neurons throughout life. We use imaging-, genome editing-, and transgenesis-based approaches as well as cellular models of human diseases using pluripotent embryonic cells to study the molecular and cellular framework of NSC biology in the developing and adult brain. Aim of our research is to understand how physiologic and disease-associated alterations of neurogenesis are translated into stem cell-associated plastic changes in the developing and adult brain on a molecular, cellular, and behavioral level.

How and why to use human cellular models to study SYNGAP1

CELLULAR STRESS PATHWAYS AND VESICULAR TRAFFICKING DEFECTS IN HUMAN CELLULAR MODELS OF CNTNAP1-ASSOCIATED CONGENITAL HYPOMYELINATING NEUROPATHY TYPE 3

FENS Forum 2026

DO CONVERGENT OR DIVERGENT PROTEOMIC EFFECTS UNDERLY ALTERED NEURONAL EXCITABILITY OF CORTICAL EXCITATORY AND INHIBITORY CELLULAR MODELS OF MYOCLONUS DYSTONIA?

FENS Forum 2026

INFLAMMATORY STRESS SIGNALING ASSOCIATED WITH Α-SYNUCLEIN BURDEN IN CELLULAR MODELS OF PARKINSON’S DISEASE

FENS Forum 2026

VIRAL-MEDIATED MODULATION OF MT5-MMP AS A POTENTIAL THERAPEUTIC APPROACH IN TRANSGENIC AND CELLULAR MODELS OF ALZHEIMER’S DISEASE

FENS Forum 2026

L-CARNITINE AND LINOLEIC ACID RESCUES PATHOLOGICAL IRON ACCUMULATION AND LIPID PEROXIDATION IN CELLULAR MODELS OF NEMALINE MYOPATHY

FENS Forum 2026

NAP: Advanced cellular models for studying individual sleep dynamics

FENS Forum 2024

Cystathionine beta-synthase and H2S levels are increased in cellular models of Trisomy 21

FENS Forum 2024

Extracellular vesicles and transmission of α-synuclein pathology: From cellular models to diagnostic applications

FENS Forum 2024

Human IPSCs-derived oligodendrocytes and astrocytes as the first Autosomal Dominant Leukodystrophy-relevant cellular models