cellular models
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Molecular and cellular mechanisms controlling neural stem cell activity
Neural stem cells (NSCs) generate new neurons throughout life. We use imaging-, genome editing-, and transgenesis-based approaches as well as cellular models of human diseases using pluripotent embryonic cells to study the molecular and cellular framework of NSC biology in the developing and adult brain. Aim of our research is to understand how physiologic and disease-associated alterations of neurogenesis are translated into stem cell-associated plastic changes in the developing and adult brain on a molecular, cellular, and behavioral level.
How and why to use human cellular models to study SYNGAP1
Human IPSCs-derived oligodendrocytes and astrocytes as the first Autosomal Dominant Leukodystrophy-relevant cellular models
Extracellular vesicles and transmission of α-synuclein pathology: From cellular models to diagnostic applications
FENS Forum 2024
NAP: Advanced cellular models for studying individual sleep dynamics
FENS Forum 2024
Cystathionine beta-synthase and H2S levels are increased in cellular models of Trisomy 21
FENS Forum 2024
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