cholesterol metabolism

Microglial efferocytosis: Diving into the Alzheimer's Disease gene pool

Genome-wide association studies and functional genomics studies have linked specific cell types, genes, and pathways to Alzheimer’s disease (AD) risk. In particular, AD risk alleles primarily affect the abundance or structure, and thus the activity, of genes expressed in macrophages, strongly implicating microglia (the brain-resident macrophages) in the etiology of AD. These genes converge on pathways (endocytosis/phagocytosis, cholesterol metabolism, and immune response) with critical roles in core macrophage functions such as efferocytosis. Here, we review these pathways, highlighting relevant genes identified in the latest AD genetics and genomics studies, and describe how they may contribute to AD pathogenesis. Investigating the functional impact of AD-associated variants and genes in microglia is essential for elucidating disease risk mechanisms and developing effective therapeutic approaches." https://doi.org/10.1016/j.neuron.2022.10.015

The APP A673T variant and the APOE genotype affect astrocyte morphology and cholesterol metabolism in a model of Alzheimer’s disease

The ApoE ε4 genetic polymorphism alters cholesterol metabolism and cholinergic signalling pathway promoting neurotoxic effects

Cholesterol metabolism is modulated by NGF in an astrocyte-derived cell line and exhibits a neuroprotective role against oxidative stress

Striatal modulation of brain cholesterol metabolism during abstinence reduces cocaine seeking in rats