chronic stress
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Reversing chronic stress effects through life-style interventions
Stress deceleration theory: chronic adolescent stress exposure results in decelerated neurobehavioral maturation
Normative development in adolescence indicates that the prefrontal cortex is still under development thereby unable to exert efficient top-down inhibitory control on subcortical regions such as the basolateral amygdala and the nucleus accumbens. This imbalance in the developmental trajectory between cortical and subcortical regions is implicated in expression of the prototypical impulsive, compulsive, reward seeking and risk-taking adolescent behavior. Here we demonstrate that a chronic mild unpredictable stress procedure during adolescence in male Wistar rats arrests the normal behavioral maturation such that they continue to express adolescent-like impulsive, hyperactive, and compulsive behaviors into late adulthood. This arrest in behavioral maturation is associated with the hypoexcitability of prelimbic cortex (PLC) pyramidal neurons and reduced PLC-mediated synaptic glutamatergic control of BLA and nucleus accumbens core (NAcC) neurons that lasts late into adulthood. At the same time stress exposure in adolescence results in the hyperexcitability of the BLA pyramidal neurons sending stronger glutamatergic projections to the NAcC. Chemogenetic reversal of the PLC hypoexcitability decreased compulsivity and improved the expression of goal-directed behavior in rats exposed to stress during adolescence, suggesting a causal role for PLC hypoexcitability in this stress-induced arrested behavioral development. (https://www.biorxiv.org/content/10.1101/2021.11.21.469381v1.abstract)
Microbiome and behaviour: Exploring underlying mechanisms
Environmental insults alter brain function and behaviour inboth rodents and people. One putative underlying mechanism that has receivedsubstantial attention recently is the gut microbiota, the ecosystem ofsymbiotic microorganisms that populate the intestinal tract, which is known toplay a role in brain health and function via the gut-brain axis. Two keyenvironmental insults known to affect both brain function and behaviour, andthe gut microbiome, are poor diet and psychological stress. While there isstrong evidence for interactions between the microbiome and host physiology inthe context of chronic stress, little is known about the role of the microbiomein the host response to acute stress. Determining the underlying mechanisms bywhich stress may provoke functional changes in the gut and brain is criticalfor developing therapeutics to alleviate adverse consequences of traumaticstress.
Sex-Specific Brain Transcriptional Signatures in Human MDD and their Correlates in Mouse Models of Depression
Major depressive disorder (MDD) is a sexually dimorphic disease. This sexual dimorphism is believed to result from sex-specific molecular alterations affecting functional pathways regulating the capacity of men and women to cope with daily life stress differently. Transcriptional changes associated with epigenetic alterations have been observed in the brain of men and women with depression and similar changes have been reported in different animal models of stress-induced depressive-like behaviors. In fact, most of our knowledge of the biological basis of MDD is derived from studies of chronic stress models in rodents. However, while these models capture certain aspects of the features of MDD, the extent to which they reproduce the molecular pathology of the human syndrome remains unknown and the functional consequences of these changes on the neuronal networks controlling stress responses are poorly understood. During this presentation, we will first address the extent by which transcriptional signatures associated with MDD compares in men and women. We will then transition to the capacity of different mouse models of chronic stress to recapitulate some of the transcriptional alterations associated with the expression of MDD in both sexes. Finally, we will briefly elaborate on the functional consequences of these changes at the neuronal level and conclude with an integrative perspective on the contribution of sex-specific transcriptional profiles on the expression of stress responses and MDD in men and women.
Reward processing in psychosis: adding meanings to the findings
Much of our daily behavior is driven by rewards. The ability to learn to pursue rewarding experiences is, in fact, an essential metric of mental health. Conversely, reduced capacity to engage in adaptive goal-oriented behavior is the hallmark of apathy, and present in the psychotic disorder. The search for its underlying mechanisms has resulted in findings of profound impairments in learning from rewards and the associated blunted activation in key reward areas of the brain of patients with psychosis. An emerging research field has been relying on digital phenotyping tools and ecological momentary assessments (EMA) that map patients’ current mood, behavior and context in the flow of their daily lives. Using these tools, we have started to see a different picture of apathy, one that is exquisitely driven by the environment. For one, reward sensitivity appears to be blunted by stressors, and exposure to undue chronic stress in the daily life may result in apathy in those predisposed to psychosis. Secondly, even patients with psychosis who exhibit clinically elevated levels of apathy are perfectly capable of seeking out and enjoying social interactions in their daily life, if their environment allows them to do so. The use of digital phenotyping tools in combination with neuroimaging of apathy not only allows us to add meanings to the neurobiological findings, but could also help design rational interventions.
Age-dependent dynamics in acute and chronic stress-induced FOSB/∆FOSB content in the extended amygdala, hypothalamic paraventricular, habenular, centrally-projecting Edinger-Westphal and dorsal raphe nuclei in male rats
Chemogenetic control of TMNHA neurons activity affects maladaptive cognitive responses to chronic stress in mice
Chronic stress triggers dismantlement of the calyceal junction between type I vestibular hair cells and calyx afferent terminals
Early life chronic stress alters zebrafish dorsal raphe serotonergic neuron responses to subsequent stressor exposure
Effects of chronic stress on hippocampal microglia and neurogenesis of mice under social defeat stress
Global proteome profiling of the temporal cortex of female rats exposed to chronic stress and a western diet
miRNA-186-5p – a new culprit of chronic stress-induced synaptic dysfunction
Pharmacological and genetic probing of the role of Nociceptin/orphaninFQ receptors in chronic stress-induced memory deficits
Platinum Nanoparticle-Based Microreactors Protect Against the Behavioral and Neurobiological Consequences of Chronic Stress Exposure
Predicting chronic stress among healthy females using daily-life physiological and lifestyle features from wearable sensors
Prefrontal inhibitory circuits are impacted by chronic stress and drive stress-associated behavioral impairments
Region-specific CREB function regulates distinct forms of regret associated with resilience versus susceptibility to chronic stress
Sphk2 deletion is involved in structural abnormalities and Th17 response but does not aggravate colon inflammation induced by sub-chronic stress
Behavioral, molecular and cellular effects of low-dose CBD administration in a chronic stress-induced major depression mouse model
FENS Forum 2024
Behavioural control training promotes antidepressant/anxiolytic-like reversal of chronic stress-induced behavioural deficits: Endocannabinoidergic and prolactinergic mechanisms
FENS Forum 2024
Beyond maternal boundaries: Exploring offspring excitability in response to maternal chronic stress and mirtazapine
FENS Forum 2024
Impact of chronic stress and cortisol on hippocampal neuroplasticity: Implications for depression
FENS Forum 2024
Long-term (intergenerational) effects of chronic stress on mouse behavior and its interaction with the circadian gene regulation in the hippocampus
FENS Forum 2024
A novel property of rice bran: Rice bran extract improves chronic stress-induced depression and anxiety-like behaviors in mice
FENS Forum 2024
A novel role for LSD1 splicing modulation in homeostatic adaptation to chronic stress
FENS Forum 2024
Role of the serotonergic dorsal raphe nucleus in mediating the effects of developmental chronic stress in zebrafish
FENS Forum 2024
Single-cell transcriptomic profiles of the ventral hippocampus in response to prolonged chronic stress and antidepressant action
FENS Forum 2024
chronic stress coverage
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