electrophysiological properties

The Picower Institute Fall 2021 Symposium, Dendrites: Molecules, Structure, and Function

Dendrites play a central role in neuronal computation, and many complex mechanisms shape their structure, function, and connectivity. Dendrites can undergo plastic changes during development and learning, as well as during neurodevelopmental and neurodegenerative disease. We will discuss how the molecular and electrophysiological properties of dendrites enable them to perform complex computations important for sensory-motor processing and higher cognitive function, and how these can go awry.

Thalamic reticular nucleus dysfunction in neurodevelopmental disorders

The thalamic reticular nucleus (TRN), the major source of thalamic inhibition, is known to regulate thalamocortical interactions critical for sensory processing, attention and cognition. TRN dysfunction has been linked to sensory abnormality, attention deficit and sleep disturbance across multiple neurodevelopmental disorders. Currently, little is known about the organizational principles underlying its divergent functions. In this talk, I will start with an example of how dysfunction of TRN contributes to attention deficit and sleep disruption using a mouse model of Ptchd1 mutation, which in humans cause neurodevelopmental disorder with ASD. Building on these findings, we further performed an integrative single-cell analysis linking molecular and electrophysiological features of the TRN to connectivity and systems-level function. We identified two subnetworks of the TRN with segregated anatomical structure, distinct electrophysiological properties, differential connections to the functionally distinct first-order and higher-order thalamic nuclei, and differential role in regulating sleep. These studies provide a comprehensive atlas for TRN neurons at the single-cell resolution and a foundation for studying diverse functions and dysfunctions of the TRN. Finally, I will describe the newly developed minimally invasive optogenetic tool for probing circuit function and dysfunction.

Different faces of neurons expressing dopamine receptors in motor cortex – their laminar distribution, electrophysiological properties and role in skilled forelimb reaching

Altered electrophysiological properties and excitatory network function of corticomotor neurons in C9orf72 loss-of-function mice

Maturation of electrophysiological properties of motor cortex neuros allows a finer motor control in adult rats

Electrophysiological properties and activity-dependent differentiation of human induced neurons

FENS Forum 2024

Interneurons in the nucleus accumbens alter their electrophysiological properties in a mouse model of neuropathic pain

FENS Forum 2024

Network function and electrophysiological properties are impaired in corticomotor neurons of C9orf72 loss-of-function and gain-of-function ALS mouse models

FENS Forum 2024

Subpopulation of thalamic neurons possesses distinct anatomical connectivities and electrophysiological properties in the anterior thalamic nucleus

FENS Forum 2024