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Development of an Optical and Colorimetric Biosensor for the Quantification of Microrna 184 for Late Life Depression
Untitled Seminar
Giordano Lippi – Beyond transcription – microRNA mechanisms of brain development; Maria Isabel Carreño-Muñoz– Role of GABAergic circuits in the generation of sensory processing dysregulations in SYNGAP1 haploinsufficiency; Rhys Knowles-TBA; Nigel Kee- That other half: Derivation of posterior axial tissues from human stem cells
MicroRNAs as targets in the epilepsies: hits, misses and complexes
MicroRNAs are small noncoding RNAs that provide a critical layer of gene expression control. Individual microRNAs variably exert effects across networks of genes via sequence-specific binding to mRNAs, fine-tuning protein levels. This helps coordinate the timing and specification of cell fate transitions during brain development and maintains neural circuit function and plasticity by activity-dependent (re)shaping of synapses and the levels of neurotransmitter components. MicroRNA levels have been found to be altered in tissue from the epileptogenic zone resected from adults with drug-resistant focal epilepsy and this has driven efforts to explore their therapeutic potential, in particular using antisense oligonucleotide (ASOs) inhibitors termed antimirs. Here, we review the molecular mechanisms by which microRNAs control brain excitability and the latest progress towards a microRNA-based treatment for temporal lobe epilepsy. We also look at whether microRNA-based approaches could be used to treat genetic epilepsies, correcting individual genes or dysregulated pathways. Finally, we look at how cells have evolved to maximise the efficiency of the microRNA system via RNA editing, where single base changes is capable of altering the repertoire of genes under the control of a single microRNA. The findings improve our understanding of the molecular landscape of the epileptic brain and may lead to new therapies.
Neuronal RNA signatures: Regulation and Function
Neurons are uniquely complex cells characterized by the expression of RNA sequences that are found in no other cell type: neuron-specific mRNA splice isoforms, circular RNAs, microRNAs, and ultra-long 3’UTRs. Although relatively little is known about how these neuronal RNA signatures control neuronal development and function, the importance of RNA-directed regulation in the brain is exemplified by its implication in neurological diseases. Our goal is to gain mechanistic and functional insight of the neuron-specific RNA landscape that drives neural function in health and disease.
<SPAN STYLE="FONT-WEIGHT:BOLD">THE STEM CELL-EXCLUSIVE MIR-290-295 CLUSTER, UNEXPECTEDLY THE MOST SPECIFIC MICRORNAS IN MATURE DOPAMINE NEURONS WITHIN SUBSTANTIA NIGRA, CONFERS NEUROPROTECTION VIA PRESERVED PROTEIN SYNTHESIS</SPAN>
FENS Forum 2026
Altered expression of peripheral microRNAs and pathway signaling after mild traumatic brain injury
Cannabidiol modulates alterations in PFC microRNAs in a rat model of depression
Cell-type-specific profiling of microRNAs during epileptogenesis: Insights into neurons and microglia microRNA profiles in normal brain function and disease
The emerging role of microRNAs in experimental and clinical multiple sclerosis: implications for inflammation-driven synaptic dysfunctions and disease course
Effects of adolescent ethanol exposure on hippocampal microRNA expression
Functional analysis of microRNAs in auditory brainstem of mice
MicroRNA therapeutics for stratified treatment of Schizophrenia
Region-specific microRNA alterations in marmosets carrying SLC6A4 polymorphisms are associated with anxiety-like behavior
The role of MicroRNA-34a on Dorsal Raphe Nuclei neurotransmission in response to specific valence stimuli
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