TopicNeuroscience

spinal cord injury

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43Total items

40ePosters

3Seminars

Latest

SeminarNeuroscience

Mechanisms of Axon Growth and Regeneration

Frank Bradke

German Center for Neurodegenerative Diseases (DZNE)

Jan 17, 2022

Almost everybody that has seen neurons under a microscope for the first time is fascinated by their beauty and their complex shape. Early on during development, however, there are hardly any signs of their future complexity, but the neurons look round and simple. How do neurons develop their sophisticated structure? How do they initially generate domains that later have distinct function within neuronal circuits, such as the axon? And, can a better understanding of the underlying developmental mechanisms help us in pathological conditions, such as a spinal cord injury, to induce axons to regenerate? Here, I will talk about the cytoskeleton as a driving force for neuronal polarization. We will then explore how cytoskeletal changes help to reactivate the growth program of injured CNS axons to elicit axon regeneration after a spinal cord injury. Finally, we will discuss whether axon growth and synapse formation may be processes in neurons that might exclude each other. Following this developmental hypothesis, it will help us to generate a novel perspective on regeneration failure in the adult CNS, and how we can overcome this failure to induce axon regeneration. Thus, this talk will describe how we can exploit developmental mechanisms to induce axon regeneration after a spinal cord injury.

SeminarNeuroscienceRecording

NMC4 Short Talk: Decoding finger movements from human posterior parietal cortex

Charles Guan

California Institute of Technology

Dec 1, 2021

Restoring hand function is a top priority for individuals with tetraplegia. This challenge motivates considerable research on brain-computer interfaces (BCIs), which bypass damaged neural pathways to control paralyzed or prosthetic limbs. Here, we demonstrate the BCI control of a prosthetic hand using intracortical recordings from the posterior parietal cortex (PPC). As part of an ongoing clinical trial, two participants with cervical spinal cord injury were each implanted with a 96-channel array in the left PPC. Across four sessions each, we recorded neural activity while they attempted to press individual fingers of the contralateral (right) hand. Single neurons modulated selectively for different finger movements. Offline, we accurately classified finger movements from neural firing rates using linear discriminant analysis (LDA) with cross-validation (accuracy = 90%; chance = 17%). Finally, the participants used the neural classifier online to control all five fingers of a BCI hand. Online control accuracy (86%; chance = 17%) exceeded previous state-of-the-art finger BCIs. Furthermore, offline, we could classify both flexion and extension of the right fingers, as well as flexion of all ten fingers. Our results indicate that neural recordings from PPC can be used to control prosthetic fingers, which may help contribute to a hand restoration strategy for people with tetraplegia.

SeminarNeuroscience

Making spinal sensory interneurons from stem cells for regenerative therapies

Sandeep Gupta

University of California, LA

Jun 13, 2021

Dr. Gupta is carrying out his post doctoral studies in the Buter Laboratory in UCLA. He is applying his his knowledge of embryology to stem cells for developing regenerative therapies to treat spinal cord injuries. In this talk, he will discuss how understanding the logic for spinal cord development led us to derive diverse sensory neuronal classes from embryonic stem cells. The spinal sensory neurons enableus to perceive our environment through modalities that are lost in spinal injury patients. These ESC derived senory neurons can help regain sensation in spina cord injury patients through regenerative therapies.

spinal cord injury

Latest

Mechanisms of Axon Growth and Regeneration

NMC4 Short Talk: Decoding finger movements from human posterior parietal cortex

Making spinal sensory interneurons from stem cells for regenerative therapies

IMPAIRED INTRINSIC EXCITABILITY OF REMOTE NEURONS AFTER SPINAL CORD INJURY

INVESTIGATING THE MECHANISMS OF ACTION OF INTRAVENOUS STEM CELL THERAPY FOLLOWING TRAUMATIC SPINAL CORD INJURY

SPATIOTEMPORAL EXPRESSION OF THE C-TYPE LECTIN CD93 IN A MOUSE MODEL OF SPINAL CORD INJURY

CELL AND CAMP COMBINATORIAL THERAPY INDUCES CORTICOSPINAL TRACT REGENERATION AFTER SPINAL CORD INJURY

CORTICO-BRAINSTEM PATHWAY COMPENSATES FOR LOSS OF CORTICOSPINAL OUTPUT AFTER STROKE AND SPINAL CORD INJURY

FUNCTIONAL ELECTRICAL STIMULATION INDUCES SPINAL PLASTICITY AND LOCOMOTOR RECOVERY AFTER SPINAL CORD INJURY

CD9 AS A DRIVER OF NEUROPHATIC PAIN THROUGH ADAPTIVE IMMUNITY AFTER SPINAL CORD INJURY

VIRTUAL REALITY–BASED BRAIN–COMPUTER INTERFACE FOR SPINAL CORD INJURY: CLINICAL AND NEUROPHYSIOLOGICAL EFFECTS

COMPARATIVE PROTEIN KINASE C MODULATION BY PROSTRATIN AND BRYOSTATIN-1 ON MICROGLIAL ACTIVATION AND NEURITE OUTGROWTH IN <EM>IN VITRO</EM> MODELS OF SPINAL CORD INJURY

INVESTIGATING THE ALTERATIONS OF BODILY SELF-CONSCIOUSNESS IN SPINAL CORD INJURY WITH THE REAL LEG ILLUSION: AN FMRI STUDY

OPTOGENETIC THERAPY TO TREAT SPASTICITY IN A MOUSE MODEL OF SPINAL CORD INJURY

PLASTICITY OF MEDULLARY DESCENDING PATHWAYS AFTER SPINAL CORD INJURY AND TRANS-SPINAL MAGNETIC STIMULATION

ANTI-INFLAMMATORY AND NEUROPROTECTIVE EFFECTS OF INFLAMMASOME INHIBITORS FOLLOWING CONTUSION SPINAL CORD INJURY

ACTIVATION OF HYPOTHALAMIC-PONTINE-SPINAL PATHWAY PROMOTES LOCOMOTOR INITIATION AND FUNCTIONAL RECOVERY AFTER SPINAL CORD INJURY IN MICE

THE CROSSTALK BETWEEN THE EPIGENOME AND MITOCHONDRIA AS CENTRAL PLAYER IN NEURAL FATE DECISIONS OF THE AXOTOMIZED NEURONS AFTER SPINAL CORD INJURY

PROPRIOSPINAL PACAPERGIC NEURONS MEDIATE ELECTRICAL STIMULATION-ASSISTED RECOVERY OF RESPIRATION AFTER SPINAL CORD INJURY IN MICE

SYMPATHETIC INTEGRITY DETERMINES ANGIOTENSIN II RECEPTOR–MEDIATED NEUROENDOCRINE–IMMUNE RESPONSES AFTER SPINAL CORD INJURY

LOW-INTENSITY MAGNETIC STIMULATION EXERTS PATTERN-DEPENDENT EFFECTS ON TISSUE REPAIR AFTER SPINAL CORD INJURY

CIRCUIT-LEVEL MAPPING OF LOCOMOTOR NETWORK RECRUITMENT DURING NEUROMODULATORY STIMULATION AFTER SPINAL CORD INJURY

CAMP-INDUCED TRANSCRIPTIONAL PROFILING PROVIDES INSIGHTS INTO THE BIOLOGY OF SPINAL CORD INJURY HEALING

LOSS OF FUNCTION OF NOGGIN INHIBITS GLIAL SCAR FORMATION AND MOTOR FUNCTION RECOVERY AFTER SPINAL CORD INJURY

A SCALABLE MULTILAYERED HYDROGEL DELIVERING STROMAL VASCULAR FRACTION FOR SPINAL CORD INJURY REPAIR

DISTINCT REHABILITATION STRATEGIES DRIVE DIFFERENTIAL SENSORIMOTOR RECOVERY AND BRAIN ACTIVATION AFTER SPINAL CORD INJURY IN MICE

A NANOGEL-BASED DRUG DELIVERY SYSTEM FOR OLIGODENDROCYTE PRESERVATION IN SPINAL CORD INJURY

OPTOGENETIC THERAPY FOR INHIBITION OF MUSCLE SPASMS AND HYPERREFLEXIA AFTER SPINAL CORD INJURY

ENHACED SENSORIMOTOR REPRESENTATIONS IN SPINAL CORD INJURY THROUGH LUMBOSACRAL NEUROMODULATION

METABOLOMIC AND PROTEOMIC PROFILING REVEAL RECOVERY-RELATED SERUM SIGNATURES IN SPINAL CORD INJURY PATIENTS UNDER REHABILITATION

SENSORIMOTOR REHABILITATION AFTER SPINAL CORD INJURY ENHANCED BY SYNERGISTIC VIRTUAL REALITY AND TRANSCUTANEOUS ELECTRICAL STIMULATION

TARGETING LSD1 TO REDUCE NEUROINFLAMMATION AND PROMOTE FUNCTIONAL RECOVERY AFTER SPINAL CORD INJURY

REPETITIVE TRANS-SPINAL MAGNETIC STIMULATION PROMOTES REPAIR IN INFLAMMATORY SPINAL CORD INJURY THROUGH SEX-DEPENDENT IMMUNE MODULATION

CONNEXIN 43 HEMICHANNELS MODULATE THE EARLY RESPONSE OF EPENDYMAL CELLS TO SPINAL CORD INJURY

PHARMACOLOGICAL TARGETING OF THE MITO-NUCLEAR AXIS AS A KEY REGULATOR OF MOTOR FUNCTION, NEURONAL REORGANIZATION AND BIOENERGETICS AFTER SPINAL CORD INJURY

Comparative study of temporal inflammation pattern of two models of spinal cord injury: Contusion versus transection

In vivo administration of metabolic precursors ameliorates metabolic impairment following severe contusive spinal cord injury in a mouse model

Microglia-driven regulation of glial scar formation after spinal cord injury: effect of Y-27632 in regenerative processes

Transcribed messenger RNA – a potential therapeutic platform for spinal cord injury

The timing of Angiotensin II receptor regulation after severe spinal cord injury

LSD1 inhibition improves functional outcome after spinal cord injury

Dynamic ECM constructs for spinal cord injury repair

Targeted gene therapy with FGF22 into subsets of spinal interneurons improves circuit plasticity and functional recovery following spinal cord injury