spinal cord injury

N/A

A Postdoc position is now available in the Dura-Bernal Lab at the State University of New York (SUNY) Downstate Health Sciences University (Brooklyn, New York), working on a new exciting multidisciplinary project entitled "Restoring motor function after spinal cord injury using multiscale modeling to decode neural latent dynamics from motor cortex EEG." The position is funded by New York State (NYS) Department of Health (DOH) Spinal Cord Injury Research program. The project aims to improve brain-machine interface decoders by combining multiscale modeling of motor cortex circuits, analysis of low-dimensional neural manifolds associated with behavior, and realistic simulation of EEG signals.

Mechanisms of Axon Growth and Regeneration

Almost everybody that has seen neurons under a microscope for the first time is fascinated by their beauty and their complex shape. Early on during development, however, there are hardly any signs of their future complexity, but the neurons look round and simple. How do neurons develop their sophisticated structure? How do they initially generate domains that later have distinct function within neuronal circuits, such as the axon? And, can a better understanding of the underlying developmental mechanisms help us in pathological conditions, such as a spinal cord injury, to induce axons to regenerate? Here, I will talk about the cytoskeleton as a driving force for neuronal polarization. We will then explore how cytoskeletal changes help to reactivate the growth program of injured CNS axons to elicit axon regeneration after a spinal cord injury. Finally, we will discuss whether axon growth and synapse formation may be processes in neurons that might exclude each other. Following this developmental hypothesis, it will help us to generate a novel perspective on regeneration failure in the adult CNS, and how we can overcome this failure to induce axon regeneration. Thus, this talk will describe how we can exploit developmental mechanisms to induce axon regeneration after a spinal cord injury.

NMC4 Short Talk: Decoding finger movements from human posterior parietal cortex

Restoring hand function is a top priority for individuals with tetraplegia. This challenge motivates considerable research on brain-computer interfaces (BCIs), which bypass damaged neural pathways to control paralyzed or prosthetic limbs. Here, we demonstrate the BCI control of a prosthetic hand using intracortical recordings from the posterior parietal cortex (PPC). As part of an ongoing clinical trial, two participants with cervical spinal cord injury were each implanted with a 96-channel array in the left PPC. Across four sessions each, we recorded neural activity while they attempted to press individual fingers of the contralateral (right) hand. Single neurons modulated selectively for different finger movements. Offline, we accurately classified finger movements from neural firing rates using linear discriminant analysis (LDA) with cross-validation (accuracy = 90%; chance = 17%). Finally, the participants used the neural classifier online to control all five fingers of a BCI hand. Online control accuracy (86%; chance = 17%) exceeded previous state-of-the-art finger BCIs. Furthermore, offline, we could classify both flexion and extension of the right fingers, as well as flexion of all ten fingers. Our results indicate that neural recordings from PPC can be used to control prosthetic fingers, which may help contribute to a hand restoration strategy for people with tetraplegia.

Making spinal sensory interneurons from stem cells for regenerative therapies

Dr. Gupta is carrying out his post doctoral studies in the Buter Laboratory in UCLA. He is applying his his knowledge of embryology to stem cells for developing regenerative therapies to treat spinal cord injuries. In this talk, he will discuss how understanding the logic for spinal cord development led us to derive diverse sensory neuronal classes from embryonic stem cells. The spinal sensory neurons enableus to perceive our environment through modalities that are lost in spinal injury patients. These ESC derived senory neurons can help regain sensation in spina cord injury patients through regenerative therapies.

Inflammation pattern after rat spinal cord injury with a comparative analysis of contusion vs transection experimental models

Tibolone improves locomotor function in a rat model of spinal cord injury by modulating apoptosis and autophagy

FENS Forum 2024

AAV-mediated gene therapy for sensory regeneration after spinal cord injury

Acute intralesional application of extracellular vesicles improves outcomes in a rat model of traumatic spinal cord injury

Alterations of locomotion in a model of incomplete cervical spinal cord injury (SCI) in pigs

Comparative model of minimal spinal cord injury reveals superior regenerative potential of nervous tissue during development compared to adulthood

Cortical reorganization after spinal cord injury is layer-specific and time-dependent

Deactivating Mast cells and delocalizing Aquaporin-4 avoid early formation of different edema subtypes and prevents sensorimotor impairments after spinal cord injury

Dynamic ECM constructs for spinal cord injury repair

Early intravenous infusion of neuroectodermal stem cell exerts beneficial effect on neuroprotection following traumatic spinal cord injury

Effects of stroboscopic visual training on TUG and 6MWT performances in subjects with incomplete spinal cord injury evaluated using DeepLabCut markerless pose estimation system

Flexible neurotransmitter phenotype of spinal excitatory interneurons regulates locomotor ability after spinal cord injury

The genetic downregulation of calpain 1 reverts spinal hyperexcitability in a neonate mouse model of complete spinal cord injury

Inhibition of the NLRP3 inflammasome by OLT1177 induces functional protection and myelin preservation after spinal cord injury

LSD1 inhibition improves functional outcome after spinal cord injury

Microglia-driven regulation of glial scar formation after spinal cord injury: effect of Y-27632 in regenerative processes

Obstacle negotiation during locomotion before and after incomplete spinal cord injury

Oral administration of 4-methylumbelliferone combined with rehabilitation promotes anatomical plasticity and functional recovery in the chronic stage of spinal cord injury

The porcine cortical motor system: anatomy and response to spinal cord injury (SCI)

Preclinical development of a therapy for Chronic Traumatic Spinal Cord Injury using Wharton's Jelly Mesenchymal Stromal Cells: proof of concept and regulatory compliance

Resident neural stem cells guarantee the regeneration promoted by bulbar olfactory ensheathing cell transplantation after spinal cord injury

Restoration of ER proteostasis augments the autophagic flux and mitigates remote degeneration after spinal cord injury

SCInflam: Serum Changes in Inflammatory analytes in Spinal Cord Injury patients

Selective Modulation of A1 Astrocytes by Drug-Loaded Nano-Structured gel in Spinal Cord Injury

Spontaneous regeneration of cholecystokinergic descending axons after a complete spinal cord injury in lampreys

New strategy using aldynoglia cells in combination with fibrin and sulphoglycolipid inhibitor for spinal cord injury repair

A synthetic synaptic organizer protein “CPTX” restores damaged neuronal circuits from spinal cord injury : the recovery from the chronic-phase of spinal cord injury

Targeted gene therapy with FGF22 into subsets of spinal interneurons improves circuit plasticity and functional recovery following spinal cord injury

The timing of Angiotensin II receptor regulation after severe spinal cord injury

Transcribed messenger RNA – a potential therapeutic platform for spinal cord injury

In vivo administration of metabolic precursors ameliorates metabolic impairment following severe contusive spinal cord injury in a mouse model

Comparative study of temporal inflammation pattern of two models of spinal cord injury: Contusion versus transection

FENS Forum 2024

The crosstalk between the epigenome and mitochondria as central player in neural fate decisions of the axotomized neurons after spinal cord injury

FENS Forum 2024

Dynamics of immunoglobulin G distribution and neuronal internalization following spinal cord injury

FENS Forum 2024

Effect of continuous inhibition of Ia fiber activity on spasticity symptom and Ia-α motoneuron connection after spinal cord injury

FENS Forum 2024

Exploring the potential of induced neural stem cells (iNSCs) as therapy for spinal cord injury in a rat model

FENS Forum 2024

Exploring synergistic supraspinal and sensory effects on adaptive plasticity of the neuronal networks after spinal cord injury

FENS Forum 2024

Functional stimulation system for rehabilitation of gait and driving neural plasticity after spinal cord injury

FENS Forum 2024

Impact of carnosine supplementation on cellular expressions of brain- and glial cell line-derived neurotrophic factors in lumbar and cervical enlargements after thoracic spinal cord injury

FENS Forum 2024

The impact of combination therapy in spinal cord injury treatment

FENS Forum 2024